Seventeen years later, the 49ers and Cardinals reunite in Mexico City

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The 49ers will meet Arizona in Mexico City at the Estadio Azteca on Monday, Nov. 21, their first international game since 2013, the NFL announced Wednesday.

The match, which will count as a road date for the 49ers, will be their first outside the United States since beating the Jaguars 42-10 in London at Wembley Stadium nine years ago.

The 49ers and Cardinals played the NFL’s first regular season game outside the United States in 2005, also at the Estadio Azteca: Arizona won 31-14 in front of 103,467 fans, which was the most big crowd for a regular season game in NFL history. That record was broken in 2009 when 105,121 people attended the Cowboys’ regular season opener at AT&T Stadium.

The 49ers plan to train at the Air Force Academy in Colorado Springs in the week before the game to adjust to the altitude. The Estadio Azteca is located 2,200 meters above sea level. The highest elevation of an NFL stadium is Empower Field in Denver (5,280 feet).

The November meeting will mark the NFL’s fifth regular season game in Mexico City, and its first since 2019. A 2018 game, between the Chiefs and Rams, was moved from the Estadio Azteca in Los Angeles due to bad weather. field conditions.

The Estadio Azteca, which opened in 1966, hosted the football final of the 1968 Summer Olympics and two FIFA World Cups (1970, 1986).

The NFL will announce game dates and times for the 2022 schedule next Thursday. The 49ers’ opponents are set. Their non-divisional home games will be against Washington, New Orleans, Tampa Bay, Kansas City, Miami and the Los Angeles Chargers. Their non-split road matches will be against Atlanta, Carolina, Denver, Las Vegas and Chicago.

Eric Branch covers the 49ers for The San Francisco Chronicle. Email: ebranch@sfchronicle.comTwitter: @Eric_Branch

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